Course details
General
Faculty | Health Sciences | ||
Department | Medicine | ||
Education level | 2nd / Post-graduate | ||
Course code | PMHRΒ007 | Trimester | 1 |
Course title | Ovarian stimulation | ||
Independent teaching activities | Hours per week | ECTS | |
Lectures | 1 | ||
Exercises | 3 | ||
Total | 4 | 5 | |
Coursetype | General knowledge, skill acquiring | ||
Prerequisite courses | None | ||
Teaching and assessment language | English | ||
Course URL | Ovarian Stimulation |
Learning outcomes
Aim
Upon the completion of this module, the post-graduate student will possess the basic principles of ovarian stimulation on a daily practice use and he /she will be capable of managing patients undergoing ovarian stimulation with standard protocols used for this purpose.
Knowledge
The participants will acquire knowledge regarding:
- The types of gonadotrophins used for ovarian stimulation, and their differences regarding effectiveness and costs.
- The types of GnRH analogues used for ovarian stimulation and their pros and cons.
- The protocols used for ovulation induction
- Prognosis of ovarian response to gonadotrophins stimulation.
- The optimal management of poor ovarian response
- The management of premature progesterone elevation during ovarian stimulation.
- The optimal management of supporting luteal phase after ovarian stimulation
- The potential complications of ovarian stimulation
- How a modern IVF Lab is organised and operates
- What are the main ART procedures used to manage infertility
- How performance of an IVF Lab can be evaluated
Skills
The participants will be able to:
- Apply the basic principles of ovarian stimulation on everyday clinical practice.
- Evaluate and select the optimal ovarian stimulation scheme according to patient characteristics.
- Understand how the modern ART techniques are applied and evaluated.
Syllabus
- Modern management of infertility by ART
- Gonadotrophins
- GnRH analogues
- Prediction of ovarian response
- Ovarian stimulation in the poor responder
- Ovarian stimulation in the high responder
- Progesterone elevation in ovarian stimulation
- Long acting FSH
- Luteal phase support
- Ovulation induction-enhancement of ovulation
- Ovarian stimulation in practice-ESHRE Guidelines
- Technical aspects of ART: Oocyte retrieval, Sperm preparation, Fertilization, Embryo culture
- Embryo evaluation and selection for transfer. Fresh vs Frozen ET
- Cryopreservation of human gametes and embryos.
- The IVF Lab 1: Infrastructure of a modern IVF laboratory.
- The IVF Lab 2: Key Performance Indicators and their importance in an IVF laboratory.
Teaching and learning methods – evaluation
Teaching methods | Face to face Distance learning |
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Use of information and communication technologies (ICT) |
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Module structure | Work Hours per Semester | Activity |
Lectures | 40 | |
Exercises (Quiz) | 10 | |
Exercises (Online discussion fora) | 25 | |
Suggested reading | 20 | |
Final assignment | 30 | |
Overall work for the course | 125 | |
Assessment Methods |
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Suggested reading
- Shi W, Hongwei T, Zhang W, Li N, Li M, Li W, Shi J. A Prospective Randomized Controlled Study of Laser-Assisted Hatching on the Outcome of First Fresh IVF-ET Cycle in Advanced Age Women. Reprod Sci 2016.Gleicher N, Kushnir V, Albertini D, Barad DH. Improvements in IVF in women of advanced age. J Endocrinol 2016.
- Bosdou JK, Venetis CA, Dafopoulos K, Zepiridis L, Chatzimeletiou K, Anifandis G, Mitsoli A, Makedos A, Messinis IE, Tarlatzis BC et al. Transdermal testosterone pretreatment in poor responders undergoing ICSI: a randomized clinical trial. Hum Reprod 2016;31: 977-985.
- Bosch E, Labarta E, Kolibianakis E, Rosen M, Meldrum D. Regimen of ovarian stimulation affects oocyte and therefore embryo quality. Fertil Steril 2016;105: 560-570.
- Zhang J. Luteal phase ovarian stimulation following oocyte retrieval: is it helpful for poor responders? Reprod Biol Endocrinol 2015;13: 76.
- Yu X, Ruan J, He LP, Hu W, Xu Q, Tang J, Jiang J, Han J, Peng YF. Efficacy of growth hormone supplementation with gonadotrophins in vitro fertilization for poor ovarian responders: an updated meta-analysis. Int J Clin Exp Med 2015;8: 4954-4967.
- Tartagni M, Cicinelli MV, Baldini D, Tartagni MV, Alrasheed H, DeSalvia MA, Loverro G, Montagnani M. Dehydroepiandrosterone decreases the age-related decline of the in vitro fertilization outcome in women younger than 40 years old. Reprod Biol Endocrinol 2015;13: 18.
- Szymusik I, Marianowski P, Zygula A, Wielgos M. Poor responders in IVF–is there any evidence-based treatment for them? Neuro Endocrinol Lett 2015;36: 209-213.
- Nagels HE, Rishworth JR, Siristatidis CS, Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev 2015;11: CD009749.
- Nagels HE, Rishworth JR, Siristatidis CS, Kroon B. Androgens (dehydroepiandrosterone or testosterone) for women undergoing assisted reproduction. Cochrane Database Syst Rev 2015;11: CD009749.
- Merviel P, Cabry-Goubet R, Lourdel E, Devaux A, Belhadri-Mansouri N, Copin H, Benkhalifa M. Comparative prospective study of 2 ovarian stimulation protocols in poor responders: effect on implantation rate and ongoing pregnancy. Reprod Health 2015;12: 52.
- Li J, Yuan H, Chen Y, Wu H, Wu H, Li L. A meta-analysis of dehydroepiandrosterone supplementation among women with diminished ovarian reserve undergoing in vitro fertilization or intracytoplasmic sperm injection. Int J Gynaecol Obstet 2015;131: 240-245.
- Lefebvre J, Antaki R, Kadoch IJ, Dean NL, Sylvestre C, Bissonnette F, Benoit J, Menard S, Lapensee L. 450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders: a randomized controlled trial. Fertil Steril 2015;104: 1419-1425.
- Kolibianakis EM, Venetis CA, Bosdou JK, Zepiridis L, Chatzimeletiou K, Makedos A, Masouridou S, Triantafillidis S, Mitsoli A, Tarlatzis BC. Corifollitropin alfa compared with follitropin beta in poor responders undergoing ICSI: a randomized controlled trial. Hum Reprod 2015;30: 432-440.
- Giovanale V, Pulcinelli FM, Ralli E, Primiero FM, Caserta D. Poor responders in IVF: an update in therapy. Gynecol Endocrinol 2015;31: 253-257.