Course details

FacultyHealth Sciences
Education level2nd / Post-graduate
Course codePMHRA004Trimester1
Course titleMale Reproductive Endocrinology
Independent teaching activitiesHours per weekECTS
CoursetypeGeneral knowledge, skill acquiring
Prerequisite coursesNone
Teaching and assessment languageEnglish
Course URLMale Reproductive Endocrinology

Learning objectives


Upon the completion of this module, the post-graduate student will possess the basic principles of Male Reproductive Endocrinology, and, on an everyday practice level, he/she will be able to propose the basic diagnostic and therapeutic approach of cases with relevant disorders.


The participants will possess:

  • The basic principles of Male Reproductive Endocrinology in the male
  • Advanced knowledge on special topics of Male Reproductive Endocrinology (environmental and reproduction, endocrine disruptors, doping in elite sports and recreational exercise, gender incongruence)

The participants will be able to:

  • Apply the basic principles of Male Reproductive Endocrinology on everyday clinical practice
  • Evaluate and select the optimal diagnostic procedure, on the basis of sensitivity and specificity
  • Prioritize therapeutic modalities, on the basis of cost-benefit ratio
  • Transform clinical cases into meaningful clinical queries
  • Search for primary and secondary data from reliable sources
  • Critically appraise the available data


  • Introduction to male Reproductive Endocrinology
  • Male infertility
  • Imaging in male fertility
  • Medical treatment of male infertility
  • Varicocele
  • Male Accessory Gland Infections
  • Spermiogram and Andrology lab
  • Environment and male fertility
  • Thyroid disorders
  • Male hypogonadism
  • Erectile dysfunction
  • Transgender Medicine
  • Genetics in male infertility

Teaching and learning methods – evaluation

Teaching methodsFace to face
Distance learning
Use of information and
communication technologies (ICT)

  • Use of information technology for teaching - Moodle Virtual learning environment (VLE) (asynchronous learning)

  • Use of information technology for clinical training - Moodle Virtual learning environment (VLE) (asynchronous learning, wikis, Online Discussion Fora, Educational Portfolio)
  • Use of information technology for the communication with the post-graduate students (e-mail, direct messages through Moodle)
Module structureWork Hours per SemesterActivity
Lectures 40
Exercises (Quiz) 10
Exercises (Online discussion fora) 25
Exercises (Study relevant papers) 20
Final assignment30
Overall work for the course125
Assessment Methods
  • Final assignment, in English, up to 2,500 words, that will be submitted after the completion of the module

  • Knowledge evaluation during the beginning and the end of the module through short-answer questions and short assays

  • Multiple-choice questions on a weekly basis

  • Evaluation of the fora participation for each post-graduate student during the online weeks

Suggested reading

  1. Corona G, Goulis DG, Huhtaniemi I, Zitzmann M, Toppari J, Forti G, Vanderschueren D, Wu FC. European Academy of Andrology (EAA) guidelines on investigation, treatment and monitoring of functional hypogonadism in males. Andrology. 2020 Feb 5. doi: 10.1111/andr.12770.
  2. Tournaye H, Krausz C, Oates RD. Novel concepts in the aetiology of male reproductive impairment. Lancet Diabetes Endocrinol. 2016 Jul 6. pii: S2213-8587(16)30040-7. doi: 10.1016/S2213-8587(16)30040-7.
  3. Tournaye H, Krausz C, Oates RD. Concepts in diagnosis and therapy for male reproductive impairment. Lancet Diabetes Endocrinol. 2016 Jul 6. pii: S2213-8587(16)30043-2. doi: 10.1016/S2213-8587(16)30043-2.
  4. Lotti F, Frizza F, Balercia G, Barbonetti A, Behre HM, Calogero AE, Cremers JF, Francavilla F, Isidori AM, Kliesch S, La Vignera S, Lenzi A, Marcou M, Pilatz A, Poolamets O, Punab M, Peraza Godoy MF, Rajmil O, Salvio G, Shaeer O, Weidner W, Maseroli E, Cipriani S, Baldi E, Degl’Innocenti S, Danza G, Caldini AL, Terreni A, Boni L, Krausz C, Maggi M. The European Academy of Andrology (EAA) ultrasound study on healthy, fertile men: clinical, seminal and biochemical characteristics. Andrology. 2020 Apr 30. doi: 10.1111/andr.12808
  5. Boutari C, Pappas PD, Mintziori G, Nigdelis MP, Athanasiadis L, Goulis DG, Mantzoros CS. The effect of underweight on female and male reproduction. Metabolism. 2020 Apr 11;107:154229. doi: 10.1016/j.metabol.2020.154229.
  6. Mintziori G, Nigdelis MP, Mathew H, Mousiolis A, Goulis DG, Mantzoros CS. The effect of excess body fat on female and male reproduction. Metabolism. 2020 Feb 28:154193. doi: 10.1016/j.metabol.2020.154193.
  7. Kanakis GA, Nordkap L, Bang AK, Calogero AE, Bártfai G, Corona G, Forti G, Toppari J, Goulis DG, Jørgensen N. EAA clinical practice guidelines-gynecomastia evaluation and management. Andrology. 2019 Nov;7(6):778-793. doi: 10.1111/andr.12636.
  8. Wang C, Festin MP, Swerdloff RS. Male Hormonal Contraception: Where Are We Now? Curr Obstet Gynecol Rep. 2016;5:38-47. Epub 2016 Jan 29.
  9. Iliadou PK, Tsametis C, Kaprara A, Papadimas I, Goulis DG. The Sertoli cell: Novel clinical potentiality. Hormones (Athens). 2015 Oct-Dec;14(4):504-14. doi: 10.14310/horm.2002.1648.
  10. Gies I, Oates R, De Schepper J, Tournaye H. Testicular biopsy and cryopreservation for fertility preservation of prepubertal boys with Klinefelter syndrome: a pro/con debate. Fertil Steril. 2016 Feb;105(2):249-55. doi: 10.1016/j.fertnstert.2015.12.011.


Dimitrios G. Goulis