Course details

FacultyHealth Sciences
Education level2nd / Post-graduate
Course codePMHRA005Trimester1
Course titleFemale Reproductive Endocrinology
Independent teaching activitiesHours per weekECTS
CoursetypeGeneral knowledge, skill acquiring
Prerequisite coursesNone
Teaching and assessment languageEnglish
Course URLFemale Reproductive Endocrinology

Learning objectives


Upon the completion of this module, the post-graduate student will possess the basic principles of Female Reproductive Endocrinology, and, on an everyday practice level, he/she will be able to understand the rationale of the basic diagnostic and therapeutic approach of cases with relevant disorders.


The participants will possess:

  • The basic principles of Reproductive Endocrinology in the female
  • The basic principles of Reproductive Endocrinology during the peri-conceptional period
  • The basic principles of Reproductive Endocrinology during the peri-menopausal period

The participants will be able to:

  • Apply the basic principles of Female Reproductive Endocrinology on everyday clinical practice
  • Evaluate and select the optimal diagnostic procedure, on the basis of sensitivity and specificity
  • Prioritize therapeutic modalities, on the basis of cost-benefit ratio
  • Transform clinical cases into meaningful clinical queries
  • Search for primary and secondary data from reliable sources
  • Critically appraise the available data


  • Introduction to Female Reproductive Endocrinology
  • Menstrual disturbances
  • Ovarian failure
  • Pituitary tumors
  • Hyperprolactinemia
  • Functional hypothalamic amenorrhea
  • Thyroid disorders
  • Polycystic ovary syndrome
  • Hyperandogenemia
  • Endocrine diseases in pregnancy
  • Perimenopause and Menopause

Teaching and learning methods – evaluation

Teaching methodsFace to face
Distance learning
Use of information and
communication technologies (ICT)

  • Use of information technology for teaching - Moodle Virtual learning environment (VLE) (asynchronous learning)

  • Use of information technology for clinical training - Moodle Virtual learning environment (VLE) (asynchronous learning, wikis, Online Discussion Fora, Educational Portfolio)
  • Use of information technology for the communication with the post-graduate students (e-mail, direct messages through Moodle)
Module structureWork Hours per SemesterActivity
Lectures 40
Exercises (Quiz) 10
Exercises (Online discussion fora) 25
Exercises (Study relevant papers) 20
Final assignment30
Overall work for the course125
Assessment Methods
  • Final assignment, in English, up to 2,500 words, that will be submitted after the completion of the module

  • Knowledge evaluation during the beginning and the end of the module through short-answer questions and short assays

  • Multiple-choice questions on a weekly basis

  • Evaluation of the fora participation for each post-graduate student during the online weeks

Suggested reading

  1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.Fertil Steril. 2004 Jan;81(1):19-25. doi: 10.1016/j.fertnstert.2003.10.004.
  2. Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Consensus on infertility treatment related to polycystic ovary syndrome. Hum Reprod. 2008 Mar;23(3):462-77. doi: 10.1093/humrep/dem426.
  3. Garg D, Tal R. The role of AMH in the pathophysiology of polycystic ovarian syndrome. Reprod Biomed Online. 2016 Jul;33(1):15-28. doi: 10.1016/j.rbmo.2016.04.007.
  4. Boutari C, Pappas PD, Mintziori G, Nigdelis MP, Athanasiadis L, Goulis DG, Mantzoros CS. The effect of underweight on female and male reproduction. 2020 Apr 11;107:154229. doi: 10.1016/j.metabol.2020.154229.
  5. Mintziori G, Nigdelis MP, Mathew H, Mousiolis A, Goulis DG, Mantzoros CS. The effect of excess body fat on female and male reproduction. 2020 Feb 28:154193. doi: 10.1016/j.metabol.2020.154193.
  6. Karras S, Paschou SA, Kandaraki E, Anagnostis P, Annweiler C, Tarlatzis BC, Hollis BW, Grant WB, Goulis DG. Hypovitaminosis D in pregnancy in the Mediterranean region: a systematic review. Eur J Clin Nutr. 2016 Mar 2. doi: 10.1038/ejcn.2016.12.
  7. Abreu AP, Kaiser UB. Pubertal development and regulation. Lancet Diabetes Endocrinol. 2016 Mar;4(3):254-64. doi: 10.1016/S2213-8587(15)00418-0.
  8. Palioura E, Diamanti-Kandarakis E. Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs). Rev Endocr Metab Disord. 2015 Dec;16(4):365-71. doi: 10.1007/s11154-016-9326-7.
  9. Anastasiou E, Farmakidis G, Gerede A, Goulis DG, Koukkou E, Kourtis A, Mamopoulos A, Papadimitriou K, Papadopoulos V, Stefos T. Clinical practice guidelines on diabetes mellitus and pregnancy: Ι. Pre-existing type 1 and type 2 diabetes mellitus. Hormones (Athens). 2020 May 15. doi: 10.1007/s42000-020-00192-z.
  10. Mintziori G, Mousiolis A, Duntas LH, Goulis DG. Evidence for a manifold role of selenium in infertility.Hormones (Athens). 2020 Mar;19(1):55-59. doi: 10.1007/s42000-019-00140-6.


Dimitrios G. Goulis